Biography
Major research interests include:
- clinical management of head and neck, lung, and skin cancers
- innovations in radiation therapy
- combinations of targeted therapy and immunotherapy with radiation
- virally driven cancers such as HPV, EBV, and Merkel cell polyomavirus
- radiation protectants
- patient-centered decision making
- tobacco cessation
- publication and research ethics
Education
| Institution | Degree | Dept or School | End Date |
|---|---|---|---|
| University of California, San Francisco | Certificate | Diversity, Equity, and Inclusion Champion Training | 9/2020 |
| University of California, San Francisco | M.A.S. | Clinical Research | 6/2016 |
| M.D. Anderson Cancer Center | Residency | Radiation Oncology | 6/2007 |
| University of Pennsylvania | M.D. | School of Medicine | 6/2002 |
Board Certifications
- American Board of Radiology
Clinical Expertise
Brachytherapy
Bronchioloalveolar Carcinoma (BAC)
Chemoradiation
CyberKnife irradiation for lung and skull base
Electron beam and orthovoltage irradiation
External-beam radiation therapy
Head & Neck Cancer
Hyperthemia
Intensity-modulated radiation therapy
Non-Small Cell Lung Cancer
Small-Cell Lung Cancer
Program Affiliations
- Thoracic Oncology Program
- Head and Neck Oncology Program
- Visible Tumor and High-Risk Skin Cancer Program
- Department of Radiation Oncology
Grants and Funding
- Oral microbiome and inflammatory status in antimicrobially-treated oral cancer patients | NIH | 2022-06-13 - 2027-05-31 | Role: Principal Investigator
Research Narrative
In lung cancer, Dr. Yom has conducted research quantifying the risks of pneumonitis and esophagitis when chemotherapy and radiation are given simultaneously. Her research findings were important in establishing the early use of intensity-modulated radiation therapy for lung cancer in combination with 4-dimensional CT-based planning. She has particular expertise in the delivery of chemoradiation therapy for advanced-stage lung cancer, and also the delivery of non-invasive stereotactic CyberKnife radiation for early-stage lung cancer. Her hope is that better understanding of radiation toxicities will permit higher treatment doses, increase the rate of cure and improve patient quality of life. She is strongly committed to research that will lead to more effective, less toxic, and more highly individualized therapy for patients.
Dr. Yom is an investigator on many research studies in head and neck and lung cancer at UCSF, including trials related to to image-guided radiation, head and neck patients' quality of life, and combinations of novel systemic agents with radiation therapy. She is especially interested in improved clinical and translational prognostic models in order to provide more effective and individualized therapy. It is hoped that the reduction of toxicities, both through technical and biologic means, will improve patients' quality of life and potentially enable physicians to deliver more intelligently targeted radiation and chemotherapy doses in search of a better chance of cure. She believes in multidisciplinary management and a unified, team-oriented approach to patient care
Research Interests
- Head and neck and lung cancers
- Advanced imaging and radiation planning
- Radiation in combination with chemotherapy and targeted agents
- Image-guided and adaptive radiation therapy
- Radiation sensitizers and protectors
- Outcomes and quality of life
Publications
- Planet of the Apes: Lessons Learned.| |
PubMed
- Cisplatin during radiation for head and neck cancer: insights from NRG Oncology experience.| |
PubMed
- From Innovation to Evidence: The Middle Age of Stereotactic Body Radiation Therapy.| |
PubMed
- HPV-Associated Oropharyngeal Squamous Cell Carcinoma - Key Updates to the AJCC/UICC TNM9 Staging System.| |
PubMed
- Prevalence of High-Risk Human Papillomavirus and Associated Risk Factors Among Individuals With Head and Neck Cancer in a National Referral Center in Tanzania.| |
PubMed
- Consensus co-expression analysis identifies a common set of co-expressed genes associated with diabetic peripheral neuropathy and chemotherapy-induced peripheral neuropathy.| |
PubMed
- Quality of Life in Patients With p16+ Oropharyngeal Cancer Receiving Accelerated Radiation Therapy With Either Cisplatin or Cetuximab in the NRG/RTOG 1016 Randomized Controlled Trial.| |
PubMed
- The KRAS-Variant and Cetuximab in HPV-Positive Oropharyngeal Cancer: Results from the NRG/RTOG 1016 Trial.| |
PubMed
- Timely Matters: Predictors of Delay in Oral Cavity Cancer Patients Across the Care Continuum.| |
PubMed
- Response to Gao and Chen, "Comments on Akaike et al's 'Circulating tumor DNA level is associated with time to clinical recurrence in Merkel cell carcinoma: Implications for patient management'".| |
PubMed